An efficient preparation of porous polymeric microspheres by solvent evaporation in foam phase

Preparation of Eudragit E100 microspheres by modified solvent evaporation method.

The objective of this investigation was to develop the hollow microspheres as a new dosage form of floating drug delivery system with prolonged stomach retention time. Hollow microspheres containing ranitidine hydrochloride were prepared by solvent evaporation method using Eudragit RLPO dissolved in a mixture of dichloromethane and ethanol. The maximum yield and drug loading amount of hollow mi...

Formation of organic nanoparticles by solvent evaporation within porous polymeric materials.

A simple and generic method is developed to form organic nanoparticles in porous materials by solvent evaporation. The composites can be readily dissolved in water to produce aqueous organic nanoparticle dispersions.

Preparation and In-vitro Evaluation of Metformin Microspheres Using Non-Aqueous Solvent Evaporation Technique

Purpose: To prepare and evaluate metformin microspheres for prolonged release. Methods: Metformin microspheres were prepared by non-aqueous solvent evaporation method using various polymers, including ethylcellulose (EC), hydroxypropyl methylcellulose (HPMC), carbopol 934P (CA) and chitosan (CH). The effect of process variables, viz, drug/polymer ratio, stirring rate and type of polymer on the ...

Preparation and Characterization of Nitrendipine- loaded Eudragit RL 100 Microspheres Prepared by an Emulsion-Solvent Evaporation Method

Purpose: The aim of the work was to prepare nitrendipne-loaded Eudragit RL 100 microspheres to achieve sustained release nitrendipine. Method: Nitrendipne-loaded Eudragit RL 100 microspheres were prepared by an emulsion-solvent evaporation method using ethanol/liquid paraffin system. The resultant microspheres were evaluated for average particle size, drug loading, in vitro drug release and rel...

Porous Fiber Formation in Polymer-Solvent System Undergoing Solvent Evaporation